111 citations
,
February 1991 in “Headache The Journal of Head and Face Pain” Valproate significantly improved headaches in two-thirds of patients.
64 citations
,
March 1989 in “PubMed” Valproate is effective for epilepsy but has side effects and requires careful monitoring.
55 citations
,
December 1983 in “Acta Neurologica Scandinavica” Carbamazepine, valproate, and clonazepam can cause mild to serious side effects during long-term epilepsy treatment.
29 citations
,
March 1987 in “Therapeutic Drug Monitoring” Combining sodium valproate with other epilepsy drugs increases ammonia levels and side effects.
17 citations
,
January 2013 in “Indian Journal of Pharmacology” High levels of the seizure medication sodium valproate can cause hair loss.
17 citations
,
January 2008 in “Journal of the American Academy of Dermatology” Valproic acid can cause hair loss, but information on hair color change is not detailed.
16 citations
,
October 1994 in “PubMed” Sodium valproate is a safe and effective epilepsy drug with manageable side effects.
11 citations
,
January 2018 in “International journal of trichology” Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
11 citations
,
January 2016 in “Bipolar Disorder” Valproate is a mood stabilizer for bipolar disorder but has side effects and risks, especially during pregnancy.
9 citations
,
January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” Higher doses of the medication valproate can cause hair loss, which may stop when the dose is lowered or the medication is stopped.
7 citations
,
March 2018 in “Psychiatry and Clinical Psychopharmacology” Valproate can cause brain swelling with high ammonia levels, possibly underreported, especially in psychiatric patients.
7 citations
,
September 2007 Valproate sustained-release is effective and generally safe for short-term treatment of new partial epilepsy.
6 citations
,
June 2013 in “Toxicological Research” Topical Valproate is safe for human skin and unlikely to cause irritation.
5 citations
,
August 2017 in “The Journal of Clinical Psychiatry” Biotin may effectively treat hair loss caused by valproate medication.
5 citations
,
January 2016 in “Clinical psychopharmacology and neuroscience/Clinical Psychopharmacology and Neuroscience” Valproate can cause rare hair curling in some patients.
5 citations
,
June 2012 in “PubMed” Valproic acid can cause a skin condition called leukocytoclastic vasculitis, which usually gets better after stopping the drug.
4 citations
,
January 2019 in “PubMed” Low dose valproate in epileptic children mainly causes weight gain and other non-life-threatening side effects.
3 citations
,
November 2019 in “Clinical psychopharmacology and neuroscience/Clinical Psychopharmacology and Neuroscience” Valproate can cause both hair loss and curly hair in bipolar disorder patients.
2 citations
,
September 2021 in “Human Psychopharmacology: Clinical and Experimental” Valproate can cause hair problems, but there are ways to manage them.
Topical valproate can effectively promote hair growth.
2 citations
,
January 2017 in “Düşünen Adam” Agomelatine might help stop hair loss caused by valproate.
2 citations
,
April 2023 in “Curēus” Valproic acid can cause muscle damage and liver issues, which improve after stopping the drug.
2 citations
,
November 2011 in “Current psychiatry” 1 citations
,
September 2007 in “Neuromuscular disorders” The treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may improve muscle strength in children with SMA without significant side effects.
1 citations
,
April 2002 in “PubMed” Anti-epileptic drugs may cause visual and hair side effects due to enzyme inhibition, especially in genetically predisposed individuals.
July 2024 in “Drug and Chemical Toxicology” Moringa oleifera leaf extract protects skin from damage caused by sodium valproate.
June 2023 in “International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science” New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.
January 2017 in “SHILAP Revista de lepidopterología” Agomelatine might help reduce hair loss caused by valproate.
April 2024 in “Lečaŝij vrač” Valproic acid can cause low platelet counts, especially at high doses or in elderly patients.
May 2022 in “Indian Journal of Pharmacology” Sodium valproate can cause serious high blood pressure in children.