January 2004 in “Headache” Divalproex sodium significantly improved headaches in two-thirds of patients.
June 2023 in “International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science” New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.
7 citations
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September 2007 Valproate sustained-release is effective and generally safe for short-term treatment of new partial epilepsy.
29 citations
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March 1987 in “Therapeutic Drug Monitoring” Combining sodium valproate with other epilepsy drugs increases ammonia levels and side effects.
64 citations
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March 1989 in “PubMed” Valproate is effective for epilepsy but has side effects and requires careful monitoring.
2 citations
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November 2011 in “Current psychiatry” 2 citations
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September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
170 citations
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June 1974 in “BMJ” Sodium valproate effectively reduces seizures in epilepsy, especially in absences and myoclonic types, with minimal side effects.
59 citations
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October 1976 in “Acta Neurologica Scandinavica” Sodium valproate reduced seizures in many patients with resistant epilepsy.
September 2018 in “Practical diabetes” Sodium valproate is not recommended as a first-line treatment for neuropathy but may be used in resistant cases.
9 citations
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January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” Higher doses of the medication valproate can cause hair loss, which may stop when the dose is lowered or the medication is stopped.
Sodium valproate improved epilepsy control in most children but often caused weight gain and other mild side effects.
44 citations
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December 1975 in “Developmental Medicine & Child Neurology” Sodium valproate effectively controls petit mal seizures in children but is less effective for other types, with minimal side effects.
January 2011 in “Arqueología, historia y viajes sobre el mundo medieval/Arqueología, historia y viajes sobre el mundo medieval” Sodium valproate can cause severe liver disease and side effects, sometimes leading to death.
Levetiracetam and valproate sodium both reduce seizures when added to lamotrigine, but levetiracetam has fewer side effects.
18 citations
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January 2009 in “Acta neurologica Scandinavica” Long-term sodium valproate treatment for epilepsy generally caused mild and temporary side effects.
16 citations
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February 2009 in “Clinical neurology and neurosurgery” Switching to extended-release divalproex sodium improved patient-reported tremor but did not change seizure frequency or most side effects.
45 citations
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July 2025 in “Journal of Medicinal Chemistry” Vepdegestrant may become the first FDA-approved PROTAC degrader, marking a new era in drug development.
3 citations
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October 1976 in “BMJ” Sodium valproate can cause low platelets and hair loss.
169 citations
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August 1981 in “BMJ” Sodium valproate improved epilepsy control but often caused weight gain in children.
123 citations
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June 2006 in “Journal of Neurobiology” Progesterone protects brain cells, but Provera does not.
2 citations
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January 2017 in “Düşünen Adam” Agomelatine might help stop hair loss caused by valproate.
19 citations
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April 2011 in “Headache The Journal of Head and Face Pain” Both topiramate and divalproex sodium effectively reduce migraine frequency and are generally well-tolerated.
59 citations
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October 1976 in “BMJ” Sodium valproate can cause low platelet count.
76 citations
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May 2011 in “Liver transplantation” Liver transplantation is a viable option for children with propionic acidemia, improving quality of life and diet, but does not remove all risks and long-term brain outcomes are uncertain.
January 2017 in “SHILAP Revista de lepidopterología” Agomelatine might help reduce hair loss caused by valproate.
19 citations
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December 1999 in “International Journal of Dermatology” Dihydroxyacetone in self-tanning lotion helped reduce sun-related skin issues in a woman with variegate porphyria.
29 citations
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October 2009 in “Pharmacology Biochemistry and Behavior” 16 citations
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November 2018 in “The journal of pain/Journal of pain” 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.
2 citations
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November 2025 in “Pharmacology Research & Perspectives” Avacopan may cause unexpected side effects, so early monitoring is important.