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Did you mean Vascular Endothelial Growth Factor?

GlossaryVascular Endothelial Growth Factor

stimulates new blood vessel formation

Vascular Endothelial Growth Factor (VEGF) is a protein that stimulates the formation of new blood vessels. It plays a crucial role in both normal processes like wound healing and the growth of hair, as well as in pathological conditions such as cancer, where it can promote tumor growth by increasing blood supply.

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research Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study

58 citations , May 2004 in “British Journal of Dermatology”

Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

research Use of natural molecules as anti-angiogenic inhibitors for vascular endothelial growth factor receptor

16 citations , December 2012 in “Bioinformation”

Curcumin, EGCG, barringtozenol, and finasteride are effective VEGFR inhibitors.

research Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells

6 citations , August 2022 in “International journal of molecular sciences”

α-Phellandrene may help prevent hair loss by increasing growth factors and cell growth in hair cells through a specific signaling pathway.

Urotensin II Promotes the Proliferation and Secretion of Vascular Endothelial Growth Factor in Rat Dermal Papilla Cells by Activating the Wnt-Beta-Catenin Signaling Pathway

research Urotensin II promotes the proliferation and secretion of vascular endothelial growth factor in rat dermal papilla cells by activating the Wnt-β-catenin signaling pathway

June 2023 in “Italian Journal of Medicine”

Urotensin II increases growth and VEGF production in rat skin cells by turning on the Wnt-β-catenin pathway.

research Intrinsic Modulators of Hair Growth: Roles of Growth Factors, Cytokines, Chemokines, and Interferons

July 2025 in “International Journal of Trichology”

Biological factors are crucial for developing new hair restoration treatments.

research Desmodesmus pannonicus Water Extract Inhibits Melanin Synthesis and Promotes Wound Healing

1 citations , November 2024 in “Life”

Desmodesmus pannonicus water extract may help reduce skin pigmentation, heal wounds, and promote hair growth.

research Identification of bioactive compounds from thai plant extracts with hair growth promoting activity on human hair dermal papilla cells

January 2013

Thai plant extracts, especially Avicennia marina, can promote hair growth by inhibiting certain enzymes and boosting growth factors.

research Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

508 citations , June 2009 in “Current drug metabolism”

Tyrosine kinase inhibitors effectively treat cancers but often cause skin and other side effects.

research Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

322 citations , January 1997 in “Thrombosis and Haemostasis”

Angiogenesis can be controlled by balancing stimulators like VPF/VEGF and inhibitors like TSP.

research In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach

30 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

research 6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression

7 citations , December 2017 in “Anais da Academia Brasileira de Ciências”

6-Gingerol from ginger may slow down hair growth by affecting certain enzymes and growth factors.

research Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies

December 2025 in “Biomedicines”

Tyrosine kinase inhibitors for endocrine tumors often cause skin issues, requiring early management and treatment adjustments.

Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice

research Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice

June 2023 in “Food frontiers”

Ginsenoside CK, found in Panax ginseng, can prevent hair loss by controlling certain growth pathways and promoting hair follicle development.

research Novel Mechanism of Action of Dutasteride for Inducing Hair Growth in Patients with Female-Pattern Hair Loss

January 2020 in “Journal of Clinical Dermatology”

Dutasteride helps increase hair density in patients with female-pattern hair loss by activating a new growth mechanism.

research Hair-growth stimulation by conditioned medium from vitamin D3-activated preadipocytes in C57BL/6 mice

11 citations , March 2015 in “Life sciences”

Vitamin D3-activated cell byproduct promotes hair growth in mice by increasing blood vessel growth.

research [Finasteride inhibits microvascular density and VEGF expression in the seminal vesicle of rats].

May 2018 in “PubMed”

Finasteride reduces blood vessel formation in seminal vesicles.

research Adverse Hair Reactions to New Targeted Therapies for Cancer

1 citations , March 2019 in “Actas Dermo-Sifiliográficas”

New cancer treatments are less harmful to hair but can still cause hair loss, color, shape, and growth changes.

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

42 citations , April 2012 in “Seminars in Oncology”

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

research Recurrent inverse necrotizing infundibular crystalline folliculitis

1 citations , April 2024 in “Journal of Cutaneous Pathology”

Recurrent NICF is a rare skin condition with unclear causes, involving follicle inflammation and crystal deposits.

research [Androgenetic alopecia].

May 2002 in “PubMed”

Androgenetic alopecia, or hair loss, is caused by genetic factors and hormones, with different mechanisms in men and women, and can be linked to insulin resistance and polycystic ovary syndrome.

research The role of VEGF and thrombospondins in skin angiogenesis

164 citations , December 2000 in “Journal of Dermatological Science”

Targeting blood vessels may help treat skin diseases.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells

3 citations , January 2017 in “Yonsei Medical Journal”

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

research 258 11β-hydroxysteroid dehydrogenase type 1 inhibition attenuates the adverse effects of glucocorticoids on dermal papilla cells

1 citations , September 2017 in “Journal of Investigative Dermatology”

Blocking a specific enzyme can reduce the negative impact of stress hormones on hair growth cells.

research Axitinib-induced repigmentation of grey hair in a patient with metastatic renal cell carcinoma

June 2025 in “BMJ Case Reports”

Axitinib treatment turned a man's grey hair back to black.

research Referee report. For: Molecular mediators involved in skin healing: a narrative review [version 1; peer review: 1 approved with reservations]

January 2022 in “Faculty of 1000 Research Ltd”

Understanding molecular mediators can improve skin healing treatments.