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Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.

A child with a rare vitamin D-resistant condition improved with treatment.

The VDR gene polymorphism does not affect BDNF levels in autoimmune thyroiditis and hypothyroidism patients.

HVDRR is caused by VDR gene mutations, leading to vitamin D resistance, treatable with high calcium doses, but alopecia remains permanent.

Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

Vitamin D and calcium are crucial for proper skin wound healing.

A rare genetic mutation causes resistance to vitamin D, leading to severe rickets and requires high doses of calcium and vitamin D for management.

Mutations at Val-889 and Arg-752 disrupt key interactions in androgen receptor dimerization.

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

RXR and RAR proteins in skin may help with cell growth, hair growth, and gland function.

RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.

RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

Keratin heterodimers are preferred for their specific and structural advantages.

RXR agonists may promote hair growth in humans.

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

Keratins K4 and K13 form stable dimers in mature esophageal cells, aiding cell stability.

XEDAR triggers a specific signaling pathway in cells.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

A rare gene variant causes sexual development issues in siblings, needing personalized treatment.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

Type I and Type II keratin chains can form heterodimers despite sequence differences.

A new mutation in the XEDAR gene might cause a rare skin condition called hypohidrotic ectodermal dysplasia.

A gene mutation worsens skin irritation in mice due to a lack of certain fats.

Raltitrexed conjugates are less potent than the free drug but more effective at high concentrations.

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.