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GlossaryVellus Follicles

small hair follicles producing fine, short, lightly pigmented hairs

Vellus follicles are small hair follicles that produce fine, short, and lightly pigmented hairs known as vellus hairs. These hairs cover most of the human body and are often referred to as "peach fuzz." Unlike terminal hairs, which are thicker and darker, vellus hairs play a minimal role in thermoregulation and are more prominent in children and women.

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Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

research Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

9 citations , January 1992 in “Journal of Investigative Dermatology”

Sugar molecule helps hair growth, less in balding, returns with treatment.

research Compound Follicles in Folliculitis Decalvans Do Not Contain Vellus and Retained Telogen Follicles—A Pilot Histopathologic Series on Polytrichia

October 2024 in “Journal of Cutaneous Pathology”

Compound follicles in folliculitis decalvans mainly have active hair follicles.

research The Formation of Vellus Hair Follicles from Human Adult Epidermis1

73 citations , July 1956 in “Journal of Investigative Dermatology”

Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.

research Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

107 citations , May 1999 in “Archives of Dermatological Research”

Basal cell carcinoma may start from parts of tiny hair follicles.

research Epithelial skirt and bulge of human facial vellus hair follicles and and associated Merkel cell-nerve complex

48 citations , July 1993 in “Archives of Dermatological Research”

Merkel cells are abundant in facial vellus hair follicles, especially during the anagen phase.

research 561 Vellus-to-terminal hair follicle reconversion does occur in male pattern balding in a new humanized mouse model of androgenetic alopecia and is promoted by minoxidil and PRP

November 2022 in “Journal of Investigative Dermatology”

Minoxidil and PRP can help convert miniaturized hair follicles back to normal in male pattern baldness.

Vellus-To-Terminal Hair Follicle Reconversion Occurs In Male Pattern Balding And Is Promoted By Minoxidil And Platelet-Rich Plasma: In Vivo Evidence From A New Humanized Mouse Model Of Androgenetic Alopecia

research Vellus-to-terminal Hair Follicle Reconversion Occurs in Male Pattern Balding and is Promoted by Minoxidil and Platelet-rich Plasma: In Vivo Evidence from a New Humanized Mouse Model of Androgenetic Alopecia

October 2023 in “Acta dermato-venereologica”

Minoxidil and platelet-rich plasma can help turn thin hair into thicker hair in male pattern baldness.

research Human hair follicle: reservoir function and selective targeting

97 citations , September 2011 in “British Journal of Dermatology”

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

research Cell Movement in the Hair Follicle Dermis – More Than a Two-Way Street?

47 citations , December 2003 in “Journal of Investigative Dermatology”

DS cells in hair follicles can help form and restore hair, especially in hair loss conditions.

Quantification of Hair Follicle Parameters Using Computer Image Analysis: A Comparison of Androgenetic Alopecia with Normal Scalp Biopsies

research Quantification of hair follicle parameters using computer image analysis: A comparison of androgenetic alopecia with normal scalp biopsies

13 citations , August 1995 in “Australasian Journal of Dermatology”

Hair follicles are smaller in people with androgenetic alopecia compared to those with normal scalps.

research Histology of the Human Hair Follicle

9 citations , June 2008 in “Springer eBooks”

Understanding hair follicle structure is key for treating hair disorders and could help develop new treatments.

research Pharmacological aspects of hair follicle growth

7 citations , January 1989

Minoxidil and 4-MA can help treat hair loss.

research Do we need hair follicle stem cells and hair follicle neogenesis to cure common hair loss disorders?

3 citations , May 2008 in “Hair transplant forum international”

Common hair loss disorders may not need stem cell therapy, but could benefit from other treatments like hair cycle control and immune restoration therapy.

research Hair regrowth in male and female pattern hair loss does not involve the conversion of vellus hair to terminal hair

14 citations , January 2016 in “Experimental Dermatology”

Hair regrowth doesn't convert thin hairs to thick hairs, but increases overall hair density.

research Eruptive vellus hair cysts: An underdiagnosed entity

2 citations , January 2022 in “International journal of trichology”

Eruptive vellus hair cysts are often missed in diagnoses.

Spatiotemporal Secondary Hair Follicle Development in the Lanyu Pig: A Novel Pelage Hair Follicle Model

research Spatiotemporal secondary hair follicle development in the Lanyu pig (Sus scrofa taivanus): a novel pelage hair follicle model

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

The Lanyu pig's hair follicles are similar to human ones, making it useful for studying skin healing.

research Eruptive vellus hair cysts in an unusual location with atypical pathological features

January 2018 in “The Kaohsiung journal of medical sciences”

A young man had a rare case of hair cysts on his elbows, which was hard to diagnose and treat.

research Hormonal Effects on Hair Follicles

102 citations , July 2020 in “International journal of molecular sciences”

Hormones like testosterone and estrogen significantly affect hair growth and structure.

research Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles

95 citations , January 2009 in “Journal of Biomedical Optics”

Nanoparticles penetrate hair follicles better when their size matches the cuticula thickness.

research Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells

56 citations , July 2005 in “Experimental Dermatology”

Injected human hair follicle cells can create new, small hair follicles in skin cultures.

research Trichofolliculoma: a rare variant of hair follicle hamartoma

18 citations , January 2013 in “Dermatology Online Journal”

Trichofolliculoma is a rare skin bump on the face or scalp.

research COEXISTENCE OF TRICHOSTASIS SPINULOSA AND ERUPTIVE VELLUS HAIR CYSTS

17 citations , December 1994 in “International Journal of Dermatology”

Recognizing both trichostasis spinulosa and eruptive vellus hair cysts together is crucial for accurate diagnosis and treatment.

research Variation of Hair Follicle Counts among Different Scalp Areas: A Quantitative Histopathological Study

11 citations , September 2021 in “Skin Appendage Disorders”

Hair count values should be standardized for each scalp region to evaluate hair disorders in Asians.

research Hair Follicle Miniaturization in a Woolly Hair Nevus

6 citations , February 2016 in “American Journal of Dermatopathology”

The boy with woolly hair nevus had thinner hair and abnormal hair follicles, which improved with treatment but worsened when treatment stopped.

research Evaluation of Hair Follicle Counts of Occipital Scalp Biopsies from Male Hair Transplant Patients in Thailand

1 citations , February 2023 in “Siriraj Medical Journal/San Sirirat”

Thai males with hair loss have lower hair density in the occipital scalp compared to other Asians.

Effects of Platelet-Rich Plasma on Hair Follicle Count and Hair Ratios in Androgenic Alopecia: Alone or Combined with Other Treatments

research Effects of platelet-rich plasma application on hair follicle count, telogen/anagen ratio, and miniaturized hair ratio in patients with androgenic alopecia: alone or in combination with other treatments

July 2025 in “Journal of Dermatological Treatment”

PRP improves hair growth in androgenic alopecia, especially when combined with minoxidil.

The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia

research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment

August 2019 in “Research Square (Research Square)”

Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.