October 2022 in “Benha Journal of Applied Sciences” People with non-scarring hair loss have higher levels of DKK-1, a protein linked to hair growth, than those with scarring hair loss or no hair loss.
April 2021 in “Journal of Investigative Dermatology” Krox20 is crucial for hair growth and maintaining skin stem cells.
March 2021 in “Uludağ Üniversitesi Tıp Fakültesi dergisi” The review provided information on various treatments to stop hair thinning and increase hair density in people with common genetic hair loss.
September 2019 in “Encyclopedia of Life Sciences” Wound healing involves complex signaling that stops bleeding, reduces damage, and repairs skin, sometimes without scarring.
December 2018 in “Zenodo (CERN European Organization for Nuclear Research)” Low-level laser therapy may help hair growth, but more research is needed.
Pvalb8 is essential for zebrafish hearing and hair cell development, and its mutation causes hearing loss.
January 2023 in “Iranian Journal of Pharmaceutical Research” Stauntonia hexaphylla extract can help treat hair loss by blocking certain hormones.
January 2015 in “Hair transplant forum international” Female pattern hair loss is different from male pattern hair loss and has unclear genetic causes.
173 citations
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August 2015 in “Developmental cell” The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.
161 citations
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August 2012 in “Seminars in cell & developmental biology” Hair growth and development are controlled by specific signaling pathways.
90 citations
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December 2008 in “Journal of Investigative Dermatology” Thyroid-stimulating hormone affects hair follicles but doesn't change hair growth or color.
85 citations
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January 2018 in “Cell stem cell” Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
51 citations
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April 2020 in “Cells” Special cell particles from macrophages can help hair grow.
31 citations
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August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
24 citations
,
January 2018 in “Development” Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
15 citations
,
December 2020 in “International journal of molecular sciences” Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.
7 citations
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January 2022 in “Molecules” Tectoridin helps human hair cells grow and makes mouse hair longer, suggesting it could treat hair loss.
3 citations
,
September 2021 in “Journal of Clinical Medicine” Epidermal signaling helps regenerate fingertip tissue.
1 citations
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December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Keeping β-catenin levels high in mammary cells disrupts their development and branching.
April 2025 in “Antioxidants” Rhus semialata gall extract and Penta-O-Galloyl-β-D-Glucose may effectively reduce hair loss.
Understanding wound healing and signaling pathways could lead to new alopecia treatments.
56 citations
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February 2012 in “Developmental biology” Sostdc1 controls the size and number of hair and mammary gland structures.
44 citations
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February 2023 in “Cell” Fingerprints form uniquely before birth due to specific genetic pathways and local signals.
18 citations
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October 2017 in “PLOS ONE” The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.
5 citations
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February 2014 in “PloS one” Eyelid cells share signaling components but differ in pathway activity.
4 citations
,
June 2023 in “Journal of developmental biology” The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.
1 citations
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October 2025 in “International Journal of Molecular Sciences” Mutating the gmds gene in zebrafish increases hair cell numbers and regeneration.
115 citations
,
December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.
2 citations
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January 2023 in “International Journal of Biological Sciences” A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.
May 2018 in “International journal of cell science & molecular biology” Early anti-aging hair treatments should focus on anti-inflammatory agents and promoting healthy hair growth cycles.