25 citations
,
August 2010 in “Journal of Biological Chemistry” Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.
3 citations
,
September 2017 in “Stem cell investigation” PDGF signaling is crucial for maintaining fat stem cells in the skin, and its level of activation can either preserve these cells or cause fibrosis.
18 citations
,
May 2023 in “Science Advances” Activating the sonic hedgehog pathway in chicken embryos can permanently change scales to feathers.
5 citations
,
April 2022 in “Frontiers in Medicine” Hair and skin healing involve complex cell interactions controlled by specific molecules and pathways, and hair follicle cells can help repair skin wounds.
January 2026 in “International Journal of Molecular Sciences” Hedgehog pathway inhibitors could be effective in treating melanoma.
17 citations
,
September 2020 in “Inflammation and Regeneration” WNT activation in scalp fibroblasts boosts hair growth by increasing FGF9.
September 2023 in “Frontiers in bioengineering and biotechnology” JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.
Lhx2 is essential for effective Sonic Hedgehog signaling in early retinal development.
21 citations
,
November 2021 in “Cells” Hedgehog pathway inhibitors can treat certain aggressive cancers but face limitations like resistance and side effects.
May 2025 in “Science Advances” PIEZO1 helps keep hair follicle stem cells inactive, affecting hair growth.