research Bridging the organoid translational gap: integrating standardization and micropatterning for drug screening in clinical and pharmaceutical medicine
Standardizing and engineering organoids can improve their use in medicine and drug testing.
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research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines
New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
research Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benoxaprofen.
research Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma
The new formulation greatly improved quercetin absorption in rats.
research Profiling steroid and thyroid hormones with hair analysis in a cohort of women aged 25 to 45 years old
The method can measure multiple hormones in women's hair and may help identify hormone-related health issues.
research Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
Loss of Dnmt3a and Dnmt3b leads to more aggressive skin tumors, but blocking PPAR-γ can reduce this effect.
research Finasteride
research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention
Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.
research Tributyltin (TBT) effects on Ocinebrina aciculata (Gastropoda: Muricidae): imposex development, sterilization, sex change and population decline
Tributyltin exposure causes sex changes, sterilization, and decline in the snail Ocinebrina aciculata, risking its extinction.
research Smoking and the skin
Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.
research Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists
Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
research Circadian clock-mediated control of stem cell division and differentiation: beyond night and day
The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.
research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?
PPAR agonists show promise for skin conditions but need more research before being a main treatment.
research Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle
Certain transporters are found in human hair follicles and may affect hair growth and loss.
research Role of Plant Growth-Promoting Rhizobacteria (PGPR) as BioFertilizers in Stabilizing Agricultural Ecosystems
Using PGPR as biofertilizers can improve soil health and plant growth while reducing reliance on synthetic fertilizers.
research Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions
UV exposure accelerates skin aging by altering elastin, leading to wrinkles.
research Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review
Spin traps like PBN could protect skin from pollution and sunlight in cosmetics but need more research for safe use.
research Bio-Catalytic Action of Pseudomonas DL17 on Environmental Contaminant Sunset Yellow FCF
Pseudomonas DL17 can completely break down the harmful dye Sunset Yellow FCF in 48 hours.
research Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia
Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.
research A hair-follicle reconstructed in vitro immunocompetent skin model for prediction of the sensitizing potential of chemicals
The new skin model can predict how chemicals might cause skin allergies.
research Untargeted hair lipidomics: comprehensive evaluation of the hair-specific lipid signature and considerations for retrospective analysis
research High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase
Mutations in the enzyme don't significantly change how it binds to its specific substances.
research The profile of steroid hormones in human fetal and adult ovaries
Fetal ovaries produce different hormones than adult ovaries, and endocrine-disrupting chemicals may affect this process.
research Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers
Smoking reduces antioxidants and causes DNA damage in hair follicles.
research Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis
PPARs help regulate skin health and could be used to treat skin disorders.
research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note
Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.
research Anticancer agents against malaria: time to revisit?
Anticancer drugs like methotrexate and trimetrexate could be effective and safe for treating malaria at low doses.
research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity
Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.
research A High Throughput LC-MS Platform for the Discovery of Autotaxin Inhibitors
High-throughput LC-MS screening is effective for finding new autotaxin inhibitors for asthma treatment.
research Oxygen, Metabolism, and Regeneration: Lessons from Mice
Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.