19 citations
,
August 2016 in “Health and Quality of Life Outcomes” Metformin helped improve the quality of life for Chinese women with PCOS, especially in physical health and symptoms like infertility, acne, and hair loss.
Metformin helps some women with PCOS but isn't effective for weight loss or treating acne.
60 citations
,
February 2010 in “Gynecological Endocrinology” Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.
19 citations
,
March 2007 in “Journal of diabetes science and technology” Rosiglitazone may be better than metformin for insulin resistance in PCOS, but more research is needed on certain biomarkers.
3 citations
,
July 2022 in “Problemy èndokrinologii” Metformin, a diabetes drug, may also help fight cancer, but more research is needed to understand how.
9 citations
,
January 2022 in “Reproductive Biology and Endocrinology” High levels of male hormones and irregular periods best predict how well PCOS patients will respond to metformin treatment.
May 2019 in “Pakistan Journal of Pharmaceutical Sciences” Metformin can effectively treat PCOS but may cause serious side effects like joint pain and allergic reactions.
Metformin shows promise for treating skin conditions, but more research is needed.
14 citations
,
August 2021 in “Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy” Metformin, a diabetes drug, may help prevent and treat various cancers, but more research is needed.
17 citations
,
July 2016 in “The Prostate” Metformin may lower PSA levels, possibly affecting prostate cancer development.
September 2025 in “Reproductive health of woman” Metformin reduces high male hormone levels in women with PCOS.
4 citations
,
December 2023 in “Frontiers in Pharmacology” Topical metformin effectively treats melasma with minimal side effects.
August 2023 in “Journal of Clinical Medicine” Metformin lowers prolactin in women without PCOS but not in those with PCOS, where it reduces other hormones instead.
22 citations
,
September 2014 in “Hormones” Metformin may help treat neuroendocrine tumors.
192 citations
,
September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.
October 2004 in “Australian Prescriber” Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.
11 citations
,
April 2013 in “Hormones” New information suggests that metformin might help more women with PCOS and infertility, not just those with glucose issues.
35 citations
,
January 2011 in “Clinical Endocrinology” Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.
7 citations
,
November 2003 in “Current Opinion in Obstetrics & Gynecology” Metformin helps improve symptoms and reproductive outcomes in people with polycystic ovary syndrome.
18 citations
,
March 2014 in “Current Pharmaceutical Biotechnology” Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.
May 2022 in “The Journal of Clinical Pharmacology” Metformin reduces certain hormone levels in men with early-onset hair loss.
March 2023 in “East African scholars journal of medical sciences” Metformin may help regulate periods and cause modest weight loss in PCOS patients, but more research is needed.
January 2005 in “Duo Research Archive (University of Oslo)” Metformin reduces pregnancy complications in women with PCOS.
5 citations
,
January 2006 in “Journal of obstetrics and gynaecology” Metformin can cause hair loss in some women with PCOS.
26 citations
,
January 2016 in “Indian journal of endocrinology and metabolism” Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.
September 2025 in “Scientific periodicals of Ukraine” Metformin effectively reduces hormone levels in women with PCOS.
May 2025 in “Clinical Endocrinology” Metformin lowers prolactin in men with normal hair but not in those with early hair loss.
June 2022 in “Research Square (Research Square)” The conclusion is that metformin may be useful for treating various conditions beyond diabetes and that time-tracking analysis is a good way to review drug research.
October 2004 in “Australian Prescriber” Lifestyle changes are more effective than metformin for reducing type 2 diabetes risk.