7 citations
,
January 2025 Erk signaling helps zebrafish fins regrow to the right size by using memory of the original size.
92 citations
,
March 2016 in “Developmental Cell” Zebrafish skin regeneration relies on cell behaviors and reactive oxygen species, with antioxidants reducing and hydrogen peroxide increasing regeneration.
April 2026 in “Communications Biology” The development of breeding tubercles in male zebrafish relies on a specific enzyme that processes hormones.
85 citations
,
October 2015 in “Proceedings of the National Academy of Sciences of the United States of America” NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.
19 citations
,
January 2013 in “Frontiers in Neuroanatomy” Zebrafish can help study and develop treatments for hearing loss.
21 citations
,
June 2016 in “PloS one” Zebrafish need MYC and FGF to regenerate inner ear hair cells.
77 citations
,
April 2004 in “Gene expression patterns” The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.
September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Different fish use the same genes to regrow teeth.
June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.
228 citations
,
September 2012 in “Trends in Neurosciences” Nerves are crucial for the regeneration of various body parts in many animals.
252 citations
,
April 2009 in “Seminars in Cell & Developmental Biology” The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
December 2025 in “Drug Discovery and Molecular Docking (DDMD)” Single-cell transcriptomics reveals detailed cellular diversity and key pathways in tissue regeneration.
16 citations
,
March 2021 in “EvoDevo” Different species use the same genes for tooth regeneration.
39 citations
,
April 2015 in “Regeneration” Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.
17 citations
,
December 2010 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
188 citations
,
March 2018 in “Frontiers in Immunology” Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
295 citations
,
June 2009 in “Science” Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.
85 citations
,
December 2017 in “Developmental Biology” Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.
31 citations
,
June 2017 in “Regeneration” BMP2 needs periosteal tissue to help regenerate mouse middle finger bones within a specific time.
10 citations
,
May 2019 in “Seminars in Cell & Developmental Biology” Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.
9 citations
,
November 2018 in “Drug Discovery Today” Using skin stem cells and certain molecules might lead to scar-free skin healing.
44 citations
,
January 2019 in “Journal of Translational Medicine” Macrophages are essential for successful skin growth in reconstructive surgery.
16 citations
,
January 2011 in “Archives of Dermatological Research” The study found that expanded skin regenerates similarly to normal skin, with 77 genes playing a role in the process.
56 citations
,
February 2010 in “PLOS ONE” Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.
49 citations
,
February 2008 in “Stem Cells” Wnt10b helps blood stem cells grow after injury.
27 citations
,
January 2012 in “Current Topics in Microbiology and Immunology” Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
471 citations
,
October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
94 citations
,
June 2016 in “The FASEB Journal” The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
29 citations
,
July 2014 in “PLoS ONE” Inactivating β-catenin is essential for chick retina regeneration.
21 citations
,
January 2023 in “The International Journal of Developmental Biology” The Wnt signaling pathway is crucial for regeneration and could help advance human medicine.