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Research
5 / 850 resultsresearch Identification of Pygopus 2 as a component of the ribosomal RNA transcription complex in cancer
Pygopus 2 helps ovarian cancer cells grow by aiding ribosomal RNA production, independent of Wnt signaling.
research Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes
Basonuclin may help control ribosomal RNA gene activity in skin cells.
research Whole transcriptome sequencing of different hair types in inner Mongolian cashmere goats
Hair type differences in cashmere goats are linked to keratin and cytoskeletal organization.
research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
This study investigates the role of the enzyme PADI4 in hair follicle development, highlighting its function as a negative regulator of progenitor cell proliferation. PADI4, which converts peptidylarginine to citrulline, is found in both progenitor and differentiated hair lineage cells and represses transcription during hair follicle development. The enzyme citrullinates proteins involved in mRNA processing and ribosomal biogenesis, and its absence enhances protein synthesis and ribosomal RNA transcription. Additionally, PADI4 modifies the translational repressor 4E-BP1, indicating a regulatory interaction between PADI4 activity and 4E-BP1 phosphorylation. This research provides insights into how posttranslational modifications influence progenitor cell states and tissue formation.
research 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment
Acne patients have higher skin mTORC1 activity, which is reduced by isotretinoin treatment.
Community Join
5 / 1000+ resultscommunity 18->24 six years of Fin and Minox…. I guess we can’t all be winners 😭
A user named "EgyptStar81" who has been dealing with hair loss since age 15 due to genetics, chemotherapy and finasteride/minoxidil treatment. Possible solutions such as dutasteride, oral minoxidil, hair transplants and extensions were suggested.
community 2-Deoxy-D-Ribose official Product
2-Deoxy-D-Ribose is discussed as a potential hair loss treatment, but skepticism exists due to lack of human testing. The original poster uses a combination of topical Minoxidil, oral Finasteride, topical RU58841, and other treatments, reporting some hair regrowth but not significant results.
community Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics
Rhamnose may promote hair growth and pigmentation, suggesting it as a potential hair loss treatment. The conversation discusses its potential alongside known treatments like Minoxidil, finasteride, and RU58841.
community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia
IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.
community Since there is so much hype for cosmeRNA and HMI-115...
Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.