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GlossaryRNA interference

process where small RNA molecules silence specific genes

RNA interference (RNAi) is a biological process where small RNA molecules inhibit gene expression by neutralizing targeted mRNA molecules. This mechanism effectively "silences" specific genes, preventing them from producing proteins, and is used in research and medicine to study gene function and develop treatments for diseases.

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Research

5 / 1000+ results

research RNA interference of NtNCED3 reduces drought tolerance and impairs plant growth through feedback regulation of isoprenoids in Nicotiana tabacum

17 citations , July 2018 in “Environmental and Experimental Botany”

Silencing NtNCED3-2 gene in tobacco reduces drought tolerance and impairs growth.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

69 citations , February 2008 in “The American journal of pathology”

Controlled delivery of specific RNA and IL-4 restored hair growth in mice with autoimmune alopecia.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

New treatments targeting specific genes show promise for treating keratin disorders.

research Keratins and skin disease

69 citations , January 2015 in “Cell & tissue research/Cell and tissue research”

Keratin mutations cause skin diseases and could lead to new treatments.

research Gene therapy to enhance angiogenesis in chronic wounds

36 citations , August 2022 in “Molecular Therapy — Nucleic Acids”

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

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Community Join

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community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 47 upvotes 3 years ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community Any updates on GT20029? Phase 2 results were supposed to be out by the end of Q1 2024. What happened ?

in Product 20 upvotes 2 years ago

The conversation is about the anticipation and uncertainty regarding the release of GT20029 Phase 2 results for hair loss treatment. Users express hope for its effectiveness and minimal side effects compared to other treatments like Pyri and HMI115.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 3 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

in Treatment 272 upvotes 5 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community Does CosmeRNA target the root cause of MPB?

in Chat 3 years ago

. CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

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