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GlossaryS100A4

protein involved in cell growth and cancer metastasis

S100A4 is a protein that belongs to the S100 family, which is involved in various cellular processes such as cell growth and motility. It is often associated with cancer progression and metastasis, meaning it can help cancer cells spread to other parts of the body.

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Significance of the S100A4 Protein in Psoriasis

research Significance of the S100A4 Protein in Psoriasis

45 citations , July 2009 in “Journal of Investigative Dermatology”

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

research S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma

32 citations , August 2020 in “American Journal Of Pathology”

S100A4 promotes aggressive ovarian cancer and is a potential treatment target.

research Invasion and Increased Expression of S100A4 and CYR61 in Mesenchymal Transformed Breast Cancer Cells Is Downregulated by GnRH

21 citations , April 2016 in “International Journal of Oncology”

GnRH treatment can reduce breast cancer cell invasion.

research Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the Human Hair Follicle

9 citations , July 2014 in “PubMed”

Different S100 proteins have specific roles in various parts of the hair follicle.

Depletion of S100A4+ Stromal Cells Results in Abnormal Nipple Development and Nursing Failure

research Depletion of S100A4+ Stromal Cells Results in Abnormal Nipple Development and Nursing Failure

January 2026

Lack of certain cells causes abnormal nipple development and nursing failure.

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