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HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro

research HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro

7 citations , March 2021 in “Molecular Medicine Reports”

A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.

research Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells

21 citations , December 2016 in “PLOS ONE”

Scientists made skin stem cells from other human cells with over 97% efficiency, which could help treat skin conditions.

research Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

1 citations , June 2014 in “Journal of developmental biology”

Retinoic acid helps change skin cells and is important for skin development and hair growth.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

11 citations , February 2018 in “Oncotarget”

Lower SMAD2/3 activation predicts more severe skin cancer.

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community Possible topical option for preventing BDNF-related hair loss

in Research/Science 8 upvotes 2 years ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

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