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The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness.

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men

5 citations , April 2021 in “Journal of Endocrinological Investigation”

Higher DHT levels are linked to fewer hypogonadism symptoms in men with normal testosterone levels.

research Gas chromatography/mass spectrometry based hair steroid profiling may reveal pathogenesis in hair follicles of the scalp

30 citations , April 2011 in “Rapid communications in mass spectrometry/RCM. Rapid communications in mass spectrometry”

Analyzing hair with this method can help understand and monitor scalp conditions and treatment effects.

5α-Reductase Inhibitors: A New Hope in Dermatology?

research 5alpha-reductase inhibitors - a new hope in dermatology?

15 citations , March 1997 in “International Journal of Dermatology”

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

Short-Term Clinical Assessment of Treating Female Androgenic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles

research Short-Term Clinical Assessment of Treating Female Androgenic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles

January 2024 in “Biomedicines”

Using stem cells from hair follicles to treat female hair loss is safe and effective after six months.

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community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 4 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Topical finasteride (P-3074) inhibits scalp DHT up to 70%

in Finasteride/Dutasteride 20 upvotes 5 months ago

Topical finasteride (P-3074) can inhibit scalp DHT by up to 70%, with some users experiencing systemic absorption similar to oral use. Users discuss varying application frequencies and concentrations, with some noticing side effects when overused.

community How long does topical fin reduce scalp DHT?

in Finasteride/Dutasteride 8 upvotes 1 year ago

Topical finasteride reduces scalp DHT effectively, with a suggested application of 1.5ml of 0.03% daily. It binds to scalp enzymes, potentially requiring daily or every other day application for sustained results.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 66 upvotes 2 years ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Why is scalp DHT suppression lower than systemic?

in Finasteride/Dutasteride 11 upvotes 11 months ago

Dutasteride reduces DHT more effectively in hair follicles than finasteride, but some individuals still experience hair loss despite treatment. Combining oral and topical finasteride may improve results, and some users experiment with topical dutasteride despite uncertainties about its absorption.

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