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GlossaryScalp Involvement

presence of a medical condition affecting the scalp

Scalp involvement refers to the presence of a medical condition or disease affecting the scalp. This can include symptoms like redness, itching, scaling, or hair loss, and is often seen in conditions such as psoriasis, seborrheic dermatitis, or alopecia. For professionals, it indicates that the pathology extends to the scalp, necessitating targeted treatment or further diagnostic evaluation.

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Research

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research Anti-TNF-Alpha Induced Psoriasiform Eruptions with Severe Scalp Involvement and Alopecia: Report of Five Cases and Review of the Literature

49 citations , January 2012 in “Dermatology”

Severe anti-TNF-α induced scalp eruptions often need stopping the drug and using systemic therapy to avoid scarring.

research The Significance of Scalp Involvement in Pemphigus: A Literature Review

13 citations , January 2018 in “BioMed Research International”

Scalp involvement is common in pemphigus and can lead to hair loss, with the severity of scalp lesions linked to overall disease severity.

research Scalp involvement in pemphigus: a prognostic marker

10 citations , November 2017 in “Advances in Dermatology and Allergology”

Scalp involvement in pemphigus means the disease is more severe and harder to treat.

research Associations Between Skin Microbiome and Metabolome in the Pathogenesis of Atopic Dermatitis Patients With Scalp Involvement

3 citations , January 2024 in “Allergy Asthma and Immunology Research”

Understanding the skin's bacteria and chemicals may help manage scalp issues in atopic dermatitis.

research Scalp Involvement in Primary Cutaneous Lymphomas—An Update on Clinical Presentation, Diagnostics, and Management

May 2025 in “Cancers”

Scalp involvement in primary cutaneous lymphomas is common and can be aggressive, requiring careful attention.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

in Research/Science 38 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community Dutasteride + oral minoxidil: strong regrowth by Jan 2026, then mid-scalp density loss without current shedding

in Update 3 upvotes 3 months ago

The user experienced hair regrowth with dutasteride and oral minoxidil from October 2025 to January 2026, but mid-scalp density decreased afterward despite continued treatment. Ketoconazole improves scalp condition, but stopping it worsens hair appearance.

community My 5 months hair transplant update

in Progress Pictures 25 upvotes 3 months ago

A 39-year-old from Bangalore shared his successful hair transplant journey, which included 3537 scalp and 1521 beard grafts, boosting his confidence. He also started medication alongside the transplant.

community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.

in Research/Science 218 upvotes 1 year ago

PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.

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