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GlossarySebaceous Gland Hyperplasia

enlarged oil glands causing small, yellowish facial bumps

Sebaceous Gland Hyperplasia is a condition where the sebaceous glands, which are responsible for producing oil (sebum) to lubricate the skin, become enlarged. This often results in small, yellowish bumps on the skin, typically on the face. While generally harmless, it can be mistaken for other skin conditions, and its appearance may be of cosmetic concern.

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research Next-generation Sequencing Identified a Novel EDA Mutation in a Chinese Pedigree of Hypohidrotic Ectodermal Dysplasia with Hyperplasia of the Sebaceous Glands

4 citations , January 2017 in “Acta dermato-venereologica”

A new EDA gene mutation was found in a Chinese family with a specific skin disorder.

Overexpression of Cyclooxygenase-2 in the Skin of Adult Transgenic Mice Leads to Sebaceous Gland Hyperplasia and Thinning of Hair Shafts

research 919 Overexpression of cyclooxygenase-2 in the skin of adult transgenic mice leads to sebaceous gland hyperplasia and thinning of hair shafts

April 2019 in “Journal of Investigative Dermatology”

Increasing COX-2 in mouse skin causes bigger sebaceous glands and thinner hair, but stopping COX-2 can reverse hair thinning.

research Loss of epidermal PLCg1 induced sebaceous gland hyperplasia and sparse hair

April 2017 in “Journal of dermatological science”

Removing PLCg1 from skin cells caused thicker oil glands and less hair in mice.

research 332 Generation of a gene expression signature for sebaceous glands by transcriptome comparison of psoriasis and sebaceous hyperplasia

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sebaceous gland atrophy and abnormal function may contribute to hair loss in psoriasis.

research Heparan Sulfate Regulates Hair Follicle and Sebaceous Gland Morphogenesis and Homeostasis

42 citations , July 2014 in “Journal of biological chemistry/The Journal of biological chemistry”

Heparan sulfate is important for hair growth, preventing new hair formation in mature skin, and controlling oil gland development.

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community In theory, will everyone on setipiprant be able to maintain their hair forever?

4 upvotes 10 years ago

Setipiprant may help with hair maintenance but is not a guaranteed solution for everyone. Other treatments like minoxidil, finasteride, and topical spironolactone are discussed, with varying opinions on their effectiveness.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 6 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

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