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The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner

research The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner

May 2025 in “Experimental Dermatology”

Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.

research TGFβ signaling regulates lipogenesis in human sebaceous glands cells

44 citations , January 2013 in “BMC Dermatology”

TGFβ signaling prevents sebaceous gland cells from producing fats.

research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

EGFR hyperactivation increases sebaceous gland size and sebum production in mice.

research Inhibition of lipogenesis and sebum secretion for Lotus corniculatus seed extract in vitro and in vivo

1 citations , November 2022 in “International Journal of Cosmetic Science”

Lotus corniculatus seed extract reduces oily skin by decreasing sebum production.

research Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes

284 citations , May 2002 in “Proceedings of the National Academy of Sciences”

CRH promotes fat production in skin cells, affecting conditions like acne.

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If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community possible treatment of AGA and change in sebaceous gland condition and oil production using sulfur soap

in Research/Science 4 upvotes 9 months ago

Sulfur soap may help with hair thickening and reducing scalp inflammation, but it can cause dryness. Nizoral, containing ketoconazole, is noted for its potential to reduce seborrheic dermatitis but may also cause scalp dryness and hair loss.

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learn Lipodermal base

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