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GlossarySegmental Vitiligo

localized skin depigmentation affecting one body segment

Segmental Vitiligo is a type of vitiligo characterized by the loss of skin color in patches, typically affecting only one side or segment of the body. Unlike the more common generalized vitiligo, segmental vitiligo often appears at a younger age and progresses for a few years before stabilizing. It is believed to be associated with the nervous system, and the depigmented patches usually follow a dermatomal distribution, which is the area of skin supplied by a single spinal nerve.

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research A case of simultaneously occurring lichen sclerosus and segmental vitiligo: connecting the underlying autoimmune pathogenesis

22 citations , September 2008 in “International Journal of Dermatology”

The case suggests a possible autoimmune link between lichen sclerosus and vitiligo.

Segmental Vitiligo and Hair Curling After Interferon Alpha and Ribavirin Treatment for Hepatitis C

research Segmental Vitiligo and Hair Curling After Interferon α and Ribavirin Treatment for Hepatitis C

14 citations , January 2006 in “Skinmed”

A woman developed white patches on her skin and curly hair after hepatitis C treatment, likely due to the medication interferon alpha.

Preservation of Melanoblasts in White Hair Follicles of Segmental Vitiligo Lesions: A Preliminary Study

research Preservation of melanoblasts of white hair follicles of segmental vitiligo lesions: A preliminary study

7 citations , May 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

White hair follicles in vitiligo have fewer and less functional melanocytes.

Segmental Vitiligo: Characteristics, Treatment, and Prognosis

research Segmental Vitiligo

2 citations , January 2019 in “Springer eBooks”

Segmental Vitiligo is a stable, early-onset form of vitiligo that responds well to early treatment and is ideal for repigmentation studies.

research Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair

1 citations , April 2025 in “Pigment Cell & Melanoma Research”

Managing stress and nerve activity can help treat segmental vitiligo and white hair.

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community One full year of treatment before and after

in Progress Pictures 18 upvotes 2 years ago

A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

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