6 citations
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January 2025 in “Differentiation” WNT10A is a secreted glycoprotein crucial for ectodermal organogenesis and tissue regeneration, with its significance first noted in 2006 in relation to cleft lip and palate. This review details the WNT10A gene and protein structure, expression patterns across species, and its roles in tissue and organ development. It highlights the connection between WNT10A loss-of-function mutations and human disorders such as ectodermal dysplasia syndromes, Odonto-oncho-dermal dysplasia, Schöpf-Schulz-Passarge syndrome, and selective tooth agenesis. Additionally, it discusses the association of increased WNT10A activity with conditions like fibrosis and carcinogenesis.
20 citations
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July 2013 in “European Journal of Oral Sciences” A new PAX9 gene mutation causes missing teeth and hair problems, but not skin or nail issues.
12 citations
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January 2016 in “Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie” Researchers found a new mutation in the EDA gene that likely causes missing teeth and mild skin symptoms in one family.
197 citations
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June 2009 in “American journal of human genetics” WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.
234 citations
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April 2000 in “Gene” Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.