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First Korean case of Cronkhite-Canada syndrome with colon cancer and serrated adenoma.

Cronkhite-Canada syndrome can sometimes show unusual colonic adenomatous polyps.

A patient with Cronkhite-Canada Syndrome developed colon cancer that spread to the liver, showing the need for regular cancer checks in such patients.

NEDD4 and NEDD4L help control intestinal stem cells and prevent tumors by breaking down the LGR5 receptor.

There is no standard treatment for the rare Cronkhite–Canada syndrome, which can be fatal and lead to cancer.