research The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity 36 citations , October 2008 in “European journal of paediatric neurology” Valproic acid treatment may cause temporary hair loss due to reduced zinc and biotinidase levels, which tend to normalize after 6 months.
research Serum Biotinidase Activity in Children Treated With Valproic Acid and Carbamazepine 16 citations , May 2009 in “Journal of child neurology” Valproic acid does not change biotinidase enzyme activity in children's blood.
research The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid 22 citations , September 2008 in “Brain & development” Biotin supplements increased biotin levels but did not significantly prevent hair loss in rats on valproic acid.
research Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy 73 citations , October 2001 in “Epilepsia” Children taking higher doses of valproic acid had lower biotinidase activity, which may lead to biotin deficiency, but biotin supplements could help.
research Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid 15 citations , May 2006 in “Brain & development” Valproic acid may cause hair loss by reducing biotinidase enzyme activity in rats.