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GlossarySkin Thickening

process where skin becomes thicker due to chronic irritation

Skin thickening, also known as lichenification, refers to the process where the skin becomes thicker and leathery due to chronic inflammation or repeated irritation. This condition often results from persistent scratching or rubbing, leading to an exaggerated skin cell production and a more pronounced skin texture. It is commonly seen in conditions like eczema or chronic dermatitis.

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technique to create small wounds in skin to activate collagen production and hair growth

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Research

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research RASopathic Skin Eruptions during Vemurafenib Therapy

82 citations , March 2013 in “PLoS ONE”

Vemurafenib causes skin side effects similar to RASopathies, requiring regular skin checks and UVA protection.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

research Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

27 citations , July 2017 in “Scientific Reports”

N-WASP is essential for healthy skin and preventing inflammation.

research Dorsal skin responses to subchronic ultraviolet B (UVB)-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats.

7 citations , January 2002 in “PubMed”

Prolonged UVB exposure causes significant skin changes and damage in rats.

research Correction: RASopathic Skin Eruptions during Vemurafenib Therapy

4 citations , October 2013 in “PLoS ONE”

Vemurafenib causes significant skin side effects, requiring regular dermatologist care and sun protection.

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Community Join

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community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 6 months ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community Diffuse thinning is the worst possible balding experience

in Chat 76 upvotes 2 years ago

The conversation discusses the struggle with diffuse hair thinning and the effectiveness of treatments like finasteride, minoxidil, and RU58841. Users share experiences of hair thickening and shedding stopping with these treatments, but results vary and some are skeptical.

community The Big Fat Layer II

in Research/Science 26 upvotes 5 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community One year after my hair transplant! 3633 FUE grafts

in Transplants 822 upvotes 4 years ago

User shares one-year hair transplant results with 3633 FUE grafts. Responses discuss improved appearance, hairline looking pluggy, and doctor's location in Ottawa, Canada.

community New potential hair loss treatment (news release)

in Treatment 188 upvotes 5 years ago

New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

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