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research Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

97 citations , May 2019 in “Frontiers in Cell and Developmental Biology”

Abnormal ECM and immune cell interactions can cause skin diseases.

research A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Immune cells are essential for early hair and skin development and healing.

research Eavesdropping on the conversation between immune cells and the skin epithelium

10 citations , January 2019 in “International Immunology”

Immune cells help keep skin healthy and repair it, but imbalance can cause disease.

research A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin

6 citations , June 2024 in “Biofabrication”

A small 3D skin model helps study how immune cells move in the skin.

TNC+ Fibroblasts Involved in Skin Inflammation via Neuro-Immune Interactions with T Cells

research TNC+ fibroblasts involve in skin inflammation via neuro-immune and interacting with T cells

September 2023 in “Research Square (Research Square)”

TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.

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Community Join

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community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 8 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

community HairClone developing cell replacement treatments for Hair Loss

7 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 10 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 5 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

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