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Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development

research Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development

147 citations , September 2006 in “Developmental Cell”

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

research Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

111 citations , June 2002 in “The EMBO Journal”

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

research hUC-MSC-exosomes deliver Let-7b/7f-5p to dermal papilla cells for a multi-target synergistic treatment of androgenetic alopecia

June 2026 in “Journal of Nanobiotechnology”

Exosomes from stem cells can help treat hair loss by promoting hair growth and reducing hair follicle aging.

research The Role of Smads in Skin Development

59 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

research Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway

139 citations , May 2020 in “Stem Cell Research & Therapy”

Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

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Community Join

5 / 27 results

community Minox and fin since start of January 2020, also shaved my head twice since then to get full effects of the minoxidil and reach the whole scalp easier, that’s honestly a huge key

in Progress Pictures 234 upvotes 5 years ago

User experienced significant hair regrowth using Minoxidil and Finasteride since January 2020, with no side effects reported. Shaving head twice helped Minoxidil reach scalp more effectively.

community 2.5 months topical minoxidil Progress

in Progress Pictures 439 upvotes 2 years ago

The conversation is about a user's hair regrowth after 2.5 months using topical minoxidil. Some suggest adding finasteride for long-term results, while others share their experiences with side effects or alternative treatments like dermarolling and dietary improvements.

community Progress – 24.03.21 – 29.06.22 Finasteride 1mg a day

in Progress Pictures 1075 upvotes 4 years ago

A user's progress with treating hair loss using 1mg finasteride per day, with reports of no noticeable side effects and positive results. Other users have shared their experiences with different treatments, such as Dutasteride and Minoxidil.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 3 years ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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