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research Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma

16 citations , March 2015 in “Clinical Cancer Research”

The document concludes that side effects from Smoothened inhibitor drugs for skin cancer are reversible and can be managed with a team approach to maintain quality of life.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations , May 2011 in “Clinical cancer research”

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

Smoothened Receptor Inhibitor Vismodegib for the Treatment of Basal Cell Carcinoma: A Retrospective Analysis of Efficacy and Side Effects

research Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects

8 citations , May 2019 in “Journal of dermatological treatment”

Vismodegib is effective for basal cell carcinoma but has severe side effects.

research Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

March 2023

The treatment was ineffective in humans.

research AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

60 citations , October 2020 in “Nature Communications”

AP-1 and TGFß work together to drive resistance in basal cell carcinoma, suggesting new treatment options.

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community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums

in Finasteride/Dutasteride 206 upvotes 5 years ago

Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 1 year ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

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