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research Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia

July 2025 in “Cell & Bioscience”

Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.

research Deciphering principles of morphogenesis from temporal and spatial patterns on the integument

19 citations , April 2015 in “Developmental Dynamics”

The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.

research Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development

19 citations , April 1999 in “British Journal of Dermatology”

Keratin 2e shows a unique pattern in developing fetal skin, different from other keratins.

Self-Organizing Hair Peg-Like Structures From Dissociated Skin Progenitor Cells: New Insights for Human Hair Follicle Organoid Engineering and Turing Patterning in an Asymmetric Morphogenetic Field

research Self‐organizing hair peg‐like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field

26 citations , January 2019 in “Experimental Dermatology”

Researchers created early-stage hair-like structures from skin cells, showing how these cells can self-organize, but more is needed for complete hair growth.

research A new practical classification for spatial distribution and morphology of human hair: Ahmad's LGMA classification

3 citations , October 2017 in “Journal of Cosmetic Dermatology”

Dr. Muhammad Ahmad created a hair classification system to help improve hair restoration surgery outcomes.

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community Finasteride, Neurosteroids, and Neuroplasticity - have you noticed cognitive shifts or have you continued growing?

in Basic Questions 163 upvotes 2 months ago

The conversation discusses concerns about potential cognitive and emotional effects of finasteride, with the original poster planning to monitor their cognitive performance while using the treatment. A user responds that most people do not experience cognitive shifts, though some report subtle changes.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 3 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

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