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Research

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research Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity

372 citations , December 2004 in “Nature Genetics”

research Treatment of Hirsutism With Spironolactone

183 citations , March 1982 in “JAMA”

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

research Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial

165 citations , February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

research The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women

142 citations , February 1985 in “Fertility and sterility”

Spironolactone reduced hair thickness and some testosterone levels in women with excessive hair growth.

research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

140 citations , February 2014 in “Neuron”

Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.

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Community Join

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community spironolactone vs dutasteride Which one is more effective?

in Female 1 upvotes 4 months ago

Spironolactone and dutasteride are compared for effectiveness in treating hair loss. The focus is on which treatment works better, regardless of side effects.

community Spironolactone vs finasteride - advice for female with AGA

in Treatment 2 upvotes 9 months ago

Spironolactone and finasteride are not recommended for women planning pregnancy due to birth defect risks. Both need to be stopped months before conception, and finasteride is generally not advised for women.

community Spironolactone and pregnancy planning

in Female 2 upvotes 1 year ago

A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

community spironolactone pills to topical

in Research/Science 6 upvotes 1 year ago

Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

in Female 4 upvotes 1 year ago

Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

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