The study compared centralised and local measurements of hair loss in mild to moderate alopecia areata (AA) using a Phase 2 clinical trial. Centralised measurement, performed from photographic images with a standardised protocol, showed greater consistency and smaller margins of error—50% lower than local ratings. Simulations indicated that using central ratings could reduce the likelihood of a statistically significant outcome by at least 50% depending on the clinical response endpoint. The study concludes that central rating is more appropriate in the Phase 2 learning stage of clinical development, providing accurate and consistent measurements of hair loss.
February 2008 in “Basic and clinical dermatology” Photographic imaging is crucial for documenting and managing hair loss, requiring careful preparation and standardization to be effective.
October 2022 in “Hair Transplantation” High-quality, standardized photos are crucial for effective hair transplant documentation.
January 2018 in “Surgical and Cosmetic Dermatology” The method is effective for evaluating hair loss treatments quickly and affordably.
16 citations
,
January 2011 in “International Journal of Trichology” Use good lighting, consistent positioning, and proper camera settings for effective hair disorder photos.