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Did you mean Steroid-Resistant Alopecia Areata?

GlossarySteroid-Resistant Alopecia Areata

hair loss condition unresponsive to standard corticosteroid treatments

Steroid-Resistant Alopecia Areata is a form of alopecia areata where the hair loss condition does not respond to standard corticosteroid treatments, which are typically used to reduce inflammation and suppress the immune system. This resistance can make the condition more challenging to manage, often requiring alternative therapies such as immunotherapy, biologics, or other systemic treatments.

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Research

5 / 1000+ results

research Potential Treatment of Steroid‐Resistant Alopecia Areata Using Allogeneic Exosomes Derived From Adipose Tissue Mesenchymal Stromal Cells: A Case Report

July 2026 in “Clinical Case Reports”

ADMSC-derived exosomes may effectively treat steroid-resistant alopecia areata.

research Treatment of Steroid-Resistant Beard-Restricted Alopecia Areata with Baricitinib

March 2024 in “Skin”

Baricitinib helped treat a man's beard hair loss when steroids didn't work.

Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata with Platelet-Rich Plasma

research Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP)

30 citations , August 2015 in “JAAD case reports”

Platelet-rich plasma (PRP) injections successfully treated a woman's steroid-resistant hair loss, causing hair to regrow within a month.

Resistance of Transplanted Hair Follicles to Diffuse Alopecia Areata

research Resistance of Transplanted Hair Follicles to the Onslaught of Diffuse Alopecia Areata

March 2017 in “The American Journal of Cosmetic Surgery”

Transplanted hair follicles can resist hair loss from an autoimmune condition better than natural hair.

5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis

research 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis

15 citations , October 2014 in “Hormone Molecular Biology and Clinical Investigation”

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

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Community Join

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community Strategies for Treatment Resistant Androgenic Alopecia

in Treatment 5 upvotes 3 months ago

The conversation is about a person experiencing treatment-resistant androgenic alopecia despite using high doses of dutasteride and minoxidil, along with other treatments like microneedling and purilutamide. Suggestions include considering a hair transplant, checking medication authenticity, and exploring other treatments like RU58841 or topical estradiol.

community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 9 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community Finasteride does deplete important nuero-active steroids

in Research/Science 11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 93 upvotes 4 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community The mechanism of androgenic alopecia

in Research/Science 34 upvotes 10 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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