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research Morphological characteristics and notes of the skin in preclinical toxicity assessment
Skin structure complexity and variability are crucial for assessing skin toxicity in safety tests.
research Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women
The drug BAY 1158061 is safe, well-tolerated, and shows potential for treating diseases related to prolactin.
research Skin Changes after Subcutaneous Injection of Epinephrine
Epinephrine injections can cause severe skin reactions like hair loss and necrosis.
research Fabrication and biological evaluation in vivo of an injectable keratin hydrogel as filler materials
Keratin hydrogel from human hair is a promising biocompatible material for soft tissue fillers.
research 267 Single- and multiple-ascending dose studies of DS-2325a, a KLK5 inhibitor for the treatment of Netherton syndrome
DS-2325a is safe and well-tolerated, supporting further development for Netherton Syndrome treatment.
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5 / 71 resultscommunity Is it possible to create an estrogen mesotherapy/topical that doesn't go systemic?
The conversation discusses the potential of using topical estrogen treatments for hair loss without systemic absorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.
community Why I really believe the tension theory is the cause of MPB
The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.
community Napkin math: are we using 100x more topical finasteride than necessary?
Topical finasteride concentrations are likely much higher than necessary for effective follicular DHT suppression, with current standards being 100-1000 times above the theoretical minimum. Lower concentrations (0.001-0.0025%) might still work locally while minimizing systemic exposure.
community M32, almost 3 moths, fin oral 1,25g/daily + min 2xday + keto 2% shapoo 1/week microneedling once a week
A 32-year-old man has been treating his hair loss with daily oral finasteride (1.25g), twice-daily topical minoxidil, weekly ketoconazole 2% shampoo, and weekly microneedling for almost three months, with no side effects from finasteride. He started with a Hamilton Norwood scale rating of 5 and has seen improvement without experiencing pain by using a 0.8mm needle length for microneedling.
community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems
Oral minoxidil may improve hair growth, reduce arterial stiffness, and prevent other health issues. Some users believe it is an effective treatment despite concerns about its effects on skin and blood.