research Systemic Circulating Leptin – Aiding New Dimension of Immune-Related Skin Carcinogenesis and Lipid Metabolism
High leptin levels may promote skin cancer and inflammation, suggesting potential for leptin-targeted therapies.
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research 271 The role of local and systemic leptin in androgenetic alopecia
Higher leptin levels link to hair loss.
research 165 Single-cell RNA sequencing analysis unveils highly active yet diminished CD14+CD16- circulating monocytes, independent of alopecia areata severity
Highly active but fewer CD14+CD16- monocytes are found in Alopecia Areata patients, regardless of severity.
research INVESTIGATION OF THE EFFECTS OF VISCERAL MASSAGE ON THE MORPHOFUNCTIONAL STATE OF THE SKIN AND SYSTEMIC METABOLISM
Visceral massage improves skin health and metabolism.
research Penetration and Distribution in Human Skin Focusing on the Hair Follicle
Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.
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5 / 1000+ resultscommunity Has any data on systemic absorption of pyrilutamide been published?
Pyrilutamide shows minimal systemic absorption with low plasma levels and no accumulation, suggesting it's unlikely to cause systemic side effects. However, full results are not yet published in scientific journals.
community Front page article at The New York Times (biggest circulation in the world) regarding notable results with oral minoxidil is a pretty big deal
This conversation discusses the potential benefits of using oral minoxidil and finasteride to treat hair loss, with some users sharing their own experiences in taking the medications. Others express concerns about the safety of these treatments.
community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found
The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.
community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)
Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.
community How come topical finasteride even works at all?
Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.
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3 / 801 resultslearn Dutasteride
Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
learn Neem Oil
natural substance from Neem tree with medicinal and pesticidal properties
learn Epidermal Growth Factor
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