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research Wnt target gene Ascl4 is dispensable for skin appendage development

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gene Ascl4 is not necessary for the development of hair, teeth, or mammary glands.

Elevated Mammalian Target of Rapamycin Gene Expression in Acne Vulgaris Patients

research Elevated Mammalian Target of Rapamycin (mTOR) Gene Expression in Acne Vulgaris patients

January 2023 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal”

Acne patients have higher mTOR gene expression.

research Genome-wide gene expression dataset used to identify potential therapeutic targets in androgenetic alopecia

4 citations , May 2017 in “Data in Brief”

Five molecular elements identified as potential future targets for hair loss therapy.

research Formation of regulator/target gene relationships during evolution

25 citations , October 2000 in “Gene”

Gene regulatory regions evolve faster than protein coding regions, allowing new gene relationships without changing transcription factors.

research Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

226 citations , August 2006 in “Molecular and Cellular Biology”

EGF signaling affects gene expression in skin cells, influencing hair growth and potentially cancer.

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Community Join

5 / 712 results

community The closest thing to a cure before hair cloning or genetic via?

in Treatment 9 upvotes 3 years ago

The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

in Research/Science 145 upvotes 4 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 4 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

in Research/Science 370 upvotes 4 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

in Treatment 274 upvotes 4 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

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