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Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-Linear Pharmacokinetics

research Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics

December 2025 in “The AAPS Journal”

Finasteride and dutasteride's effects are mainly due to target binding saturation and slow enzyme turnover.

A Simple Decision Tree for Identifying Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

research A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

November 2020 in “Journal of Pharmaceutical Sciences”

The decision tree can predict drug absorption issues with good accuracy but needs more validation and adjustments for other factors.

research Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions

34 citations , January 2022 in “Frontiers in Immunology”

IL-25 helps heal diabetic wounds by improving blood vessel and skin cell functions.

TWEAK-Conjugated Selenoviologen as a Novel Photosensitizer for Selective Wound Accumulation and Synergistic Healing of Drug-Resistant Bacterial Infections

research TWEAK-conjugated selenoviologen as a novel photosensitizer for selective wound accumulation and synergistic healing of drug-resistant bacterial infections

March 2026 in “Science China Materials”

SeV-Tp speeds up healing of drug-resistant infections by targeting wounds and killing bacteria with light activation.

Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

research Anti-PDGF receptor β antibody-conjugated squarticles loaded with minoxidil for alopecia treatment by targeting hair follicles and dermal papilla cells

17 citations , May 2015 in “Nanomedicine: Nanotechnology, Biology and Medicine”

Scientists created tiny particles loaded with a hair growth drug, minoxidil, that specifically target hair follicles and skin cells to potentially improve hair growth.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 40 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 487 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community The Big Fat Layer II

in Research/Science 26 upvotes 5 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community Breaking hair loss news! GT20029 is a resounding success!

in Product 132 upvotes 2 years ago

GT20029, a new hair loss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

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Experts

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94
Hair Transplant Surgeon
Dr. Rahma Targett, MD, FRACGP
Adelaide, SA, Australia

Clinics

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15
Hair Loss Treatments
Dr Joydeep Roy's Skin Clinic, New S.S.Medicos, (near Cachar high school), Malugram/ Drugs Corner, itkhola near Cachar CollegeSilchar, Assam · IN

Dr. Rahma Targett, MD, FRACGP