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Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Glucose and acetate metabolism by isolated sheep wool follicles

8 citations , April 1965 in “Archives of biochemistry and biophysics”

Sheep wool follicles can metabolize both glucose and acetate using different pathways important for wool growth.

research Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermisin vivo

2 citations , November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Mutant stem cells adapt their metabolism differently to outcompete normal cells in the skin.

research Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction

1 citations , July 2017 in “Microbial Cell Factories”

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

research Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

June 2026 in “eLife”

Red light exposure slows aging in mice by improving fat metabolism.

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community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 9 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Got my Oleic fatty acid they used in Korean study. Fuck you mice!

in Research/Science 244 upvotes 6 months ago

Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 484 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Results are in for my experiment with Creatine/Fin

in Finasteride 134 upvotes 6 years ago

Creatine use with finasteride increased DHT levels, possibly affecting hair loss. The user plans to reduce creatine to stabilize DHT and hair shedding.

community TCA 35% chemical peel, don't try this shit at home.

in Treatment 11 upvotes 5 months ago

The conversation discusses using a TCA 35% chemical peel on the scalp to potentially improve hair growth by addressing fibrosis and enhancing the effectiveness of topical treatments. The user also mentions trying microneedling and other methods like topical metformin and dutasteride for hair regrowth.

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