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research Age-Dependent Loss of the Stemness and Antimicrobial Defense Function of Dermal Fibroblasts Is Mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta

96 citations , December 2018 in “Immunity”

Targeting TGFβ can improve skin immunity in older people.

research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment

47 citations , August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research Molecular Biology of Hair Morphogenesis: Development and Cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

research Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages

115 citations , February 2016 in “Nature Communications”

Epidermal β-catenin activation changes the dermis by signaling different fibroblast types.

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 2 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 3 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Group Buy for MR antagonist finerenone

in Product 11 upvotes 2 years ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 1 month ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Hair loss causes are still a myth.

in Chat 18 upvotes 4 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.

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