research SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata 13 citations , May 2023 in “Journal of Dermatological Science” Reduced SIRT1 in hair cells may cause alopecia areata by triggering immune responses.
research Identification of Distinct Immune Signatures and Chemokine Networks in Scalp Inflammatory Diseases June 2023 in “Research Square (Research Square)” Different immune responses cause hair loss in scalp diseases, with unique patterns in scalp psoriasis possibly protecting against hair loss.
research Pathogenesis of paradoxical alopecia areata during dupilumab therapy: What is known and unknown 1 citations , January 2025 in “International Journal of Dermatology” Dupilumab can both improve and worsen alopecia areata, with higher IgE levels linked to better outcomes.
research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans 114 citations , August 2002 in “Journal of Investigative Dermatology” Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.
research Vitiligo and alopecia areata: apples and oranges? 71 citations , October 2013 in “Experimental Dermatology” Vitiligo and alopecia areata may have similar causes despite their differences.
learn Osteopontin signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss