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DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

56 citations , February 2010 in “PLOS ONE”

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

research Decision Letter: IL-18 Signaling Promotes Homing of Mature Tregs into the Thymus

May 2020

IL-18 signaling helps mature Tregs move into the thymus.

research Angelica Sinensis Promotes Cortical Regeneration Of The Thymus In Mice With Acute Thymic Involution Induced By Short-Term Rapamycin Treatment

March 2026 in “Journal of Zhejiang University (Medical Sciences)”

Angelica sinensis helps repair and regenerate the thymus in mice.

Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

32 citations , May 2012 in “PloS one”

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

research Pleiotropic Effects of the Nude Mutation

9 citations , January 1975 in “PubMed”

Nude mice are hairless due to a shared defect affecting both skin and thymus, not just thymic issues.

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