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    GlossaryThin-Layer Chromatography (TLC)

    Thin-Layer Chromatography (TLC) is a laboratory technique used to separate and identify compounds in a mixture. It involves applying a small sample to a thin layer of adsorbent material (like silica gel) coated on a glass or plastic plate. The plate is then placed in a solvent, which moves up the layer by capillary action, carrying different compounds at different rates based on their interactions with the adsorbent and the solvent. This method is widely used for analyzing the components of complex mixtures, such as in drug testing, food safety, and biochemical research.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
      Am I cooked? Considering HT

      community Am I cooked? Considering HT

      in Hair Transplants  62 upvotes 1 day ago
      A 37-year-old man is seeking advice for hair loss treatment, considering options like finasteride and topical or oral minoxidil. A user suggests consulting a doctor and monitoring blood pressure if using oral minoxidil.