37 citations
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November 1995 in “Journal of Investigative Dermatology”
Topicalfinasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
A 21-year-old started using topicalfinasteride and minoxidil for hair loss and experienced side effects like reduced libido, weaker erections, and sleep issues after one month. They are concerned and seeking advice on whether these effects will subside or if they should adjust the treatment frequency.
The user is using topicalfinasteride to manage hair loss due to concerns about side effects from oral finasteride. They seek advice on effectively applying the topical treatment to reduce shedding.
Topicalfinasteride can be effective for some, especially if oral finasteride causes side effects, but results may vary and can be slower. Combining topicalfinasteride with minoxidil is common, though some users switch to oral treatments for better results.
Topicalfinasteride concentrations are likely much higher than necessary for effective follicular DHT suppression, with current standards being 100-1000 times above the theoretical minimum. Lower concentrations (0.001-0.0025%) might still work locally while minimizing systemic exposure.