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community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 13 upvotes 6 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

community The Efficacy of Topical Rapamycin for Hair Regrowth

in Treatment 6 upvotes 3 years ago

The conversation discusses the effectiveness of topical Rapamycin for hair regrowth and color restoration. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

community Self-Experiment - Topical Rapamycin or a-KB

in Treatment 4 upvotes 4 years ago

A user plans to create a DIY topical treatment for hair loss using Rapamycin, possibly combined with alpha-ketoglutaric acid (a-KG). They discuss the concentration and formulation process for Rapamycin, considering safety and skin penetration, and intend to apply it every other day to the scalp.

community Anyone else tried BeauTop aka "Primal Hair"? I assumed their studies were faked/exaggerated but have had surprising results

in Research/Science 1 upvotes 4 years ago

A user tried BeauTop (Primal Hair) for hair loss, alongside a topical blend of finasteride, rapamycin, and caffeine, and noticed positive results. They cannot confirm BeauTop is the sole reason for improvement and are curious about others' experiences.

community TresslessGPT is now available for free

in General 386 upvotes 2 years ago

Tressless GPT is now free and accessible for hair loss advice. Treatments discussed include Minoxidil, finasteride, RU58841, dutasteride mesotherapy, topical melatonin, microneedling, and rapamycin.

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Research

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Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

12 citations , February 2014 in “PLoS ONE”

Topical rapamycin may effectively treat fibrous papules on the face.

research 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation

July 2024 in “Journal of Investigative Dermatology”

Topical melatonin may reduce skin aging by inhibiting certain cellular pathways.

research Topical metformin as a novel therapy for alopecia areata due to its immunologic effects

August 2023 in “Medical Hypotheses”

Metformin, usually used for diabetes, can also help treat hair loss from alopecia areata due to its ability to reduce inflammation and stimulate new hair growth.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations , January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

research ТУБЕРОЗНЫЙ СКЛЕРОЗ (БУРНЕВИЛЛЯ-ПРИНГЛА). ОБЗОР ЛИТЕРАТУРЫ

March 2026 in “Voprosy dermatologii i venerologii/Dermatologiâ ža̋ne veneralogiâ ma̋selelerì”

Early diagnosis, genetic testing, and personalized care are essential for managing tuberous sclerosis.

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