learn Spironolactone
powerful topical and oral anti-androgen used mostly by women
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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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a topical anti-androgen with less systemic involvement
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a novel topical treatment that inhibits DHT on androgen receptors
Research
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research Lack of endocrine systemic side effects after topical application of spironolactone in man
Topical spironolactone cream doesn't cause hormone-related side effects in the body.
research Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease
Topical spironolactone may help treat ocular graft-versus-host disease with minimal side effects.
research S125 Topical treatment of androgenetic alopecia with spironolactone
Topical spironolactone effectively treats hair loss in women.
research Topical Spironolactone in the Treatment of Evaporative Dry Eye Disease
Spironolactone may help improve symptoms and tear quality in dry eye disease.
research Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: A cross sectional‐comparative study
Using both 5% spironolactone and 5% minoxidil together is safe and more effective for treating hair loss.
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5 / 1000+ resultscommunity How strong is topical spiro? Close to God tier stack.
Topical spiro's effectiveness on androgens is discussed. User tried oral DUT, oral Min, keto/nizoral, and RU but experienced worsening hair loss and chest pains. Suggestion given to increase dutasteride and oral minoxidil dosage before considering spironolactone.
community how do RU and topical spironolactone compare?
Hair loss treatments RU and topical spironolactone were compared. No specific results or conclusions were provided.
community Why is nobody talking about topical Spironolactone?
Topical spironolactone is discussed as a hair loss treatment, with concerns about its effectiveness and side effects compared to finasteride and minoxidil. Users mention its unpleasant smell, potential systemic absorption, and suggest alternatives like pyrilutamide and alfatradiol.
community How effective is topical spironolactone for androgenic alopecia?
Topical spironolactone is discussed as a potential treatment for androgenic alopecia, with the user seeking feedback on its effectiveness. Minoxidil, finasteride, and other treatments like microneedling and keto shampoo are mentioned as alternatives.
community Topical Spironolactone 2.5% MONOTHERAPY x 1 year (MALE)- Nothing else
A male in his early 40s, who experienced side effects from finasteride, used 2.5% topical spironolactone for one year with no side effects but minimal regrowth. He plans to try a 5% spironolactone solution next.