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      research Case Report: Secondary syphilitic alopecia following non-penetrative sexual contact: a case of initial misdiagnosis

      April 2026 in “Frontiers in Medicine”
      A 26-year-old male was initially misdiagnosed with alopecia areata but was later found to have secondary syphilitic alopecia following non-penetrative sexual contact. The patient had moth-eaten patchy alopecia and a small erythematous papule on the penile frenulum. Serological tests confirmed syphilis, with an RPR titer of 1:32 and a positive TPPA. He was treated with benzathine penicillin G, 2.4 million units intramuscularly weekly for 3 weeks, resulting in complete hair regrowth within 3 months without scarring.
      Diffuse Syphilitic Alopecia

      research Alopecia syphilitica diffusa

      6 citations , April 2015 in “Infection”
      Treatment with benzylpenicillin and prednisolone cured the patient's syphilis and hair loss.

      research A rash diagnosis

      June 2017 in “The Medical Journal of Australia”
      The man's rash, hair loss, and vision issues were due to syphilis, not CMV.

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      community Approve PP405 quickly you coward

      in Satire  193 upvotes 9 months ago
      Pelage Pharmaceuticals is developing PP405, a topical treatment for hair growth, currently in Phase 2a trials. There is skepticism about the company's claims, and no fast-tracking approval timeline has been detailed.

      community Full extent of pp405 effectiveness

      in Treatment  14 upvotes 5 months ago
      The conversation discusses the potential effectiveness and future results of the hair loss treatment pp405, with questions about its impact on different hair loss stages and areas. There is anticipation for phase 3 trial results to provide more data, and hope that pp405 could enhance hair transplant outcomes.