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GlossaryTranslocator Protein

protein on mitochondria involved in cholesterol transport and stress response

The Translocator Protein (TSPO), formerly known as the Peripheral Benzodiazepine Receptor (PBR), is a protein found on the outer membrane of mitochondria, the energy-producing structures in cells. It plays a crucial role in transporting cholesterol into mitochondria, which is essential for the production of steroid hormones. TSPO is also involved in cellular stress responses and inflammation, making it a target for research in various medical fields, including neurology and oncology.

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research Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa

3 citations , July 2018 in “Biomedicine & pharmacotherapy”

Paeoniflorin protects brain cells by involving a specific protein and neurosteroids.

research Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects

25 citations , June 2017 in “Neuropharmacology”

Increasing TSPO in the brain reduces anxiety and depression.

Midazolam Ameliorates the Behavioral Deficits of a Rat Posttraumatic Stress Disorder Model Through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis

research Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis

56 citations , July 2014 in “PLoS ONE”

Midazolam reduces PTSD-like behavior in rats by acting on specific brain receptors.

research Over-expression of TSPO in the hippocampal CA1 area alleviates cognitive dysfunction caused by lipopolysaccharide in mice

18 citations , June 2016 in “Brain Research”

Increasing TSPO in the brain may help improve memory problems.

research Introduction: splintering urbanism

January 2007 in “Edward Elgar eBooks”

TSPO might help treat anxiety and depression.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 678 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

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