research Safety of Whole-Body Abrogation of the TRF1 Shelterin Protein in Wild-Type and Cancer-Prone Mouse Models
Deleting the Trf1 protein in mice is safe and may help prevent cancer without major side effects.
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5 / 8 results research The TRF1 Telomere Protein Is Essential for the Generation and Maintenance of Induced Pluripotent Stem Cells and Marks Both Pluripotent and Adult Stem Cells
TRF1 is crucial for creating and maintaining stem cells and marks both pluripotent and adult stem cells.
research Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling
Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.
research A Computational Modeling Framework to Quantify the Effects of Passaging Cell Lines
Cell characteristics change with passage numbers, affecting experiment results.
research Myotonic Dystrophy: A Progeroid Disease?
Myotonic dystrophy may be classified as a segmental progeroid disorder.
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