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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

The Extracellular Matrix Dictates Regional Competence for Tumor Initiation

research The extracellular matrix dictates regional competence for tumour initiation

24 citations , November 2023 in “Nature”

The extracellular matrix affects where tumors can start in the body.

research Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells

January 2018 in “eScholarship (California Digital Library)”

Hair follicle stem cells may cause squamous cell carcinoma due to a metabolic shift towards glycolysis.

research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations , October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research The role of Pygo2 during intestinal tumor initiation and progression in vivo

January 2016

Pygo2 is important for early growth and progression of intestinal tumors, and could be a target for treating cancers with certain mutations.

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Community Join

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community Hair loss is holding me back from enjoying life and I'm wasting away my youth

in Chat 279 upvotes 3 months ago

A 31-year-old man feels depressed due to hair loss, using topical finasteride and previously tried minoxidil. Others suggest treatments like finasteride, minoxidil, hair transplants, or embracing baldness, highlighting the importance of mental health and self-acceptance.

community I don’t even care about my hair I just like taking drugs

in Satire 3 years ago

A user's experimentation with various hair loss treatments, including medications and topical applications; as well as their desire to experience unusual sensations through the use of drugs.

community U/joaopassos444 , HATS OFF brother !!

in Research/Science 126 upvotes 5 years ago

A new hair loss treatment theory beyond minoxidil and finasteride is proposed, causing mixed reactions in the community, with some members eager to explore and support it, while others call for more research and evidence.

community Average r/bald user complaining

in Satire 398 upvotes 7 months ago

Hair loss treatments like Minoxidil, finasteride, and RU58841, focusing on their effectiveness and side effects. It also highlights the disparity in medical research funding between hair loss and conditions like endometriosis.

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Learn

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learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Thymosin Beta 4

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