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GlossaryTumor Suppressor Gene

regulates cell growth by preventing uncontrolled cell division

A tumor suppressor gene is a type of gene that helps regulate cell growth by preventing cells from dividing too quickly or in an uncontrolled way. When these genes are mutated or inactivated, it can lead to the development of cancer because the normal checks on cell division are lost. Examples include the TP53 gene, which produces a protein that can trigger cell death if DNA damage is detected, thereby preventing the propagation of potentially cancerous cells.

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Research

5 / 1000+ results

research Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment

153 citations , June 2015 in “GenomeBiology.com”

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

81 citations , November 2012 in “Journal of the National Cancer Institute”

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors

research Stem cell quiescence acts as a tumour suppressor in squamous tumours

66 citations , December 2013 in “Nature Cell Biology”

Inactive hair follicle stem cells help prevent skin cancer.

research The Vitamin D Receptor as Tumor Suppressor in Skin

55 citations , January 2020 in “Advances in experimental medicine and biology”

Vitamin D and its receptor may help prevent skin cancer.

research Roles of tumor suppressors in regulating tumor-associated inflammation

44 citations , September 2014 in “Cell Death & Differentiation”

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Stem Cell Factor

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Community Join

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community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 1 year ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community Testicular ultrasound is it necessary to do?

in Finasteride/Dutasteride 2 months ago

A 25-year-old male experienced increased testosterone and estradiol levels after starting finasteride for hair loss, leading his doctor to suggest a testicular ultrasound as a precaution. The user questions the necessity of the ultrasound, considering it potentially excessive, while others suggest it could be a useful precaution to rule out any issues.

community What makes them say exercise doesn't increase hair loss?

in Research/Science 45 upvotes 1 year ago

Exercise has minimal impact on hair loss, with weight lifting slightly increasing DHT and cardio potentially decreasing it. Finasteride and dutasteride are effective treatments for managing hair loss, even for those who exercise regularly.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community Pyrilutamide 5 months results (before, after pics)

in Progress Pictures 195 upvotes 3 years ago

Tae147 has shared results of using pyrilutamide, a 5% concentration topical solution applied twice daily, in combination with minoxidil, to reduce scalp itchiness and hair shedding. Other users have shared their experiences with the treatment, as well as questions about its availability on the market.

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