research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase
New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.
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research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
![The Synthesis of (−)-4-Methyl-8-Chloro-Trans-1,2,3,4,4a,5,6,10b-Octahydrobenzo-[f]-Quinolin-3-One-[3-14C] (LY300502-14C) via a Circuitous Route](/images/assets/73bab8dc-bdf0-45e3-8ef7-73d0d4b93cb1/small/21074.jpg)
research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route
Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.
research Bacillus/Trapa japonica Fruit Extract Ferment Filtrate enhances human hair follicle dermal papilla cell proliferation via the Akt/ERK/GSK-3β signaling pathway
The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.
research Enzymology of the hair follicle.
Hair follicles convert androgens, affecting hair loss patterns.
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5 / 1000+ resultscommunity Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.
Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.
community A repository of links to current scientific research and findings into the nature of and relating to side-effects for Finasteride/Dutasteride/5a-reductase inhibitors.
Finasteride and dutasteride, used for hair loss, can cause sexual dysfunction, depression, and suicidal thoughts, with some effects persisting after stopping. The post stresses the importance of being aware of these risks.
community 3 months 5g Min only before/after, 26 y/o
The user experienced significant hair regrowth after three months of using 5 mg oral minoxidil nightly and plans to add finasteride to maintain progress. Many recommend combining minoxidil with finasteride or dutasteride to prevent future hair loss.
community Massive study on finasteride side effects released
The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.
community 3 months progress (1mg oral fin + 2.5 mg oral min)
A 33-year-old male shared his 3-month progress using 1mg oral finasteride and 2.5mg oral minoxidil, along with supplements and serums, reporting thicker hair and new growth in thinning areas without side effects. Users suggested considering dutasteride or a hair transplant for better results, while others encouraged continuing the current regimen for at least a year.
Experts
6 / 22 results- 35Hair System Specialist
Tye Brock Meredith
Redding, CA, United States
- 25
SMP SpecialistKelsey Tyre
Wilmington, DE, United States
- 5
Hair System SpecialistDebbie, 15+ years specialising in hair toppers and alternative hair solutions, Extensive training with Wavy, Curly, and Afro hair
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East Toowoomba, QLD, Australia
- UnscoredHair System Specialist
dipu
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Uluberiya, India
- 12Hair Transplant Surgeon
Dr. Deepa, MD, MBBS
Incomplete name
Coimbatore, Tamil Nadu, India
- 1Hair System Specialist
Debbie
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United Kingdom
Clinics
6 / 13 results- 34
Hair Loss TreatmentsTye & Company Salon & Hair Loss StudioBaltimore, MD · US - 38
Hair TransplantDeb Hair hajbeültetési klinika DebrecenDebrecen · HU - 42
Hair TransplantDubai Cosmetic SurgeryDubai · AE - 51
Hair TransplantSMPHair Loss TreatmentsTop Hair ClinicBerlin, Berlin · DE - 38
Hair TransplantSMPHair Loss TreatmentsDermatologyTop Hair Loss ClinicAthens · GR - 42
Hair Loss TreatmentsHair TransplantTop Hair MontevideoMontevideo · UY
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