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GlossaryType I Keratin

Type I keratin is a fibrous protein that is a key structural component of hair, skin, and nails. It is classified as an acidic keratin and is primarily found in the hard tissues of the body, contributing to the strength and resilience of hair strands. In the context of hair loss, understanding type I keratin is relevant as it plays a crucial role in hair follicle health and integrity; any disruption in its production or structure can lead to weakened hair and increased susceptibility to hair loss. Distinguishing characteristics of type I keratin include its high tensile strength and its ability to form complex structures with other keratins, particularly type II keratins, to create the overall architecture of hair.

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Research

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research K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1

130 citations , April 2003 in “Journal of Investigative Dermatology”

Four specific keratins in hair follicles help understand hair structure and function.

research A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix

100 citations , November 1997 in “Human Genetics”

A new mutation in the hHb1 keratin gene is linked to the hair disorder monilethrix.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

research Type II Keratins Are Phosphorylated on a Unique Motif during Stress and Mitosis in Tissues and Cultured Cells

80 citations , June 2002 in “Molecular Biology of the Cell”

Type II keratins are uniquely phosphorylated during stress and mitosis, affecting their structure and function.

research Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog

70 citations , February 2007 in “Journal of Investigative Dermatology”

K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.

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Community Join

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community Dry hair after minoxidil, can i add oil something after minoxidil?

in Minoxidil 6 upvotes 3 years ago

The user experiences dry hair after using minoxidil and asks if they can use oil afterward, specifically Lanza Keratin Healing Oil. They seek advice on how long to wait before applying the oil and what type of oil to use.

community Is Biotin or Keratin shampoo better for hair health/growth

in Product 5 upvotes 2 years ago

Biotin and Keratin shampoos are discussed for hair health and growth. Users suggest shampoos alone don't significantly aid hair growth.

community Let's talk keratin products and hair loss

in Styling 2 upvotes 10 months ago

OP is considering using a keratin gel to improve hair quality and is concerned about its safety and visual impact on a slightly balding crown. Users discuss shampoo frequency, with some suggesting less frequent use for better hair health, but OP prefers regular shampoo and conditioner for silky hair.

community I’m Quitting ketoconazole shampoo

in Ketoconazole 2 upvotes 2 years ago

A user is quitting ketoconazole shampoo, believing it worsened their hair condition, and plans to use clarifying, keratin, and pH balanced moisturizing shampoos instead. Another user suggests using conditioner after ketoconazole to prevent dryness.

community 7 years on oral finasteride/topical minoxidil/ket (Pics included). Losing ground... what more can I do to stop the loss and gain more hair?

in Update 28 upvotes 4 years ago

A user's journey to try and stop their hair loss, including the use of oral finasteride, topical minoxidil, ketoconazole shampoo, Cynatine Keratin supplements, and The Ordinary's Multi-Peptide Serum for Hair Density; and advice from other users regarding trying dutasteride, oral minoxidil, and lifestyle changes.

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