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GlossaryTyrosine Kinase

enzyme that transfers phosphate groups to tyrosine on proteins

Tyrosine Kinase (TK) is an enzyme that functions by transferring a phosphate group from ATP to a specific amino acid called tyrosine on a protein. This process, known as phosphorylation, is crucial for regulating various cellular activities, including cell division, growth, and signaling pathways. Dysregulation of tyrosine kinases can lead to diseases such as cancer, making them important targets for certain therapeutic drugs.

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research Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

508 citations , June 2009 in “Current drug metabolism”

Tyrosine kinase inhibitors effectively treat cancers but often cause skin and other side effects.

research Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

88 citations , August 2019 in “Frontiers in immunology”

Tyrosine kinases are important in skin autoimmune diseases and could be targets for new treatments.

research Tyrosine kinase inhibition and grey hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia

research Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia

32 citations , September 2015 in “Dermatology”

Certain leukemia drugs can cause severe skin reactions that may require stopping treatment.

research Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata

23 citations , October 2024 in “British Journal of Dermatology”

Ritlecitinib effectively treats alopecia areata and is safe for long-term use in people 12 and older.

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